About AT-rich interactive domain-containing protein 3A
AT-rich interactive domain-containing protein 3A (ARID3A) is a protein
from Homo sapiens identified by UniProt accession
Q99856, 593 residues long.
MolForge cross-references it against 0 known binders and
246 disease associations.
Target properties
| Protein name | AT-rich interactive domain-containing protein 3A |
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| UniProt accession | Q99856 |
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| Gene | ARID3A |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (246)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- age at menopause · score 0.32
- reticulocyte measurement · score 0.31
- reticulocyte count · score 0.31
- glioblastoma multiforme · score 0.25
- primary biliary cirrhosis · score 0.25
- atopic eczema · score 0.25
- breast adenocarcinoma · score 0.25
- gastric adenocarcinoma · score 0.23
- squamous cell lung carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99856-F1 | alphafold | PREDICTED | 60.60 | — |
Amino-acid sequence (593 residues)
MKLQAVMETL LQRQQRARQE LEARQQLPPD PPAAPPGRAR AAPDEDREPE SARMQRAQMA ALAAMRAAAA GLGHPASPGG SEDGPPGSEE EDAAREGTPG SPGRGREGPG EEHFEDMASD EDMKPKWEEE EMEEDLGEDE EEEEEDYEDE EEEEDEEGLG PPGPASLGTT ALFPRKAQPP QAFRGDGVPR VLGGQERPGP GPAHPGGAAH VAPQLQPPDH GDWTYEEQFK QLYELDGDPK RKEFLDDLFS FMQKRGTPVN RIPIMAKQVL DLFMLYVLVT EKGGLVEVIN KKLWREITKG LNLPTSITSA AFTLRTQYMK YLYPYECEKR GLSNPNELQA AIDSNRREGR RQSFGGSLFA YSPGGAHGML SSPKLPVSSL GLAASTNGSS ITPAPKIKKE EDSAIPITVP GRLPVSLAGH PVVAAQAAAV QAAAAQAAVA AQAAALEQLR EKLESAEPPE KKMALVADEQ QRLMQRALQQ NFLAMAAQLP MSIRINSQAS ESRQDSAVNL TGTNGSNSIS MSVEINGIMY TGVLFAQPPA PTPTSAPNKG GGGGGGSSSN AGGRGGNTGT SGGQAGPAGL STPSTSTSNN SLP
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