About Sodium-dependent proline transporter
Sodium-dependent proline transporter (SLC6A7) is a protein
from Homo sapiens identified by UniProt accession
Q99884, 636 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Sodium-dependent proline transporter |
|---|
| UniProt accession | Q99884 |
|---|
| Gene | SLC6A7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 636 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- mitochondrial heteroplasmy measurement · score 0.25
- cutaneous melanoma · score 0.18
- inflammatory bowel disease · score 0.16
- ulcerative colitis · score 0.15
- sitting height measurement · score 0.12
- emphysema · score 0.07
- dengue disease · score 0.05
- metabolite measurement · score 0.05
- central nervous system cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99884-F1 | alphafold | PREDICTED | 86.03 | — |
Amino-acid sequence (636 residues)
MKKLQGAHLR KPVTPDLLMT PSDQGDVDLD VDFAAHRGNW TGKLDFLLSC IGYCVGLGNV WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF SSLGPLAVWK ISPLFKGAGA AMLLIVGLVA IYYNMIIAYV LFYLFASLTS DLPWEHCGNW WNTELCLEHR VSKDGNGALP LNLTCTVSPS EEYWSRYVLH IQGSQGIGSP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG KVVYFTATFP YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ ELGVPVDQVA KAGPGLAFVV YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ FAFLETIVTA VTDEFPYYLR PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL VLLDDYSASF GLMVVVITTC LAVTRVYGIQ RFCRDIHMML GFKPGLYFRA CWLFLSPATL LALMVYSIVK YQPSEYGSYR FPPWAELLGI LMGLLSCLMI PAGMLVAVLR EEGSLWERLQ QASRPAMDWG PSLEENRTGM YVATLAGSQS PKPLMVHMRK YGGITSFENT AIEVDREIAE EEESMM
Explore Sodium-dependent proline transporter with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets