About Gamma-aminobutyric acid receptor subunit gamma-3
Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3) is a protein
from Homo sapiens identified by UniProt accession
Q99928, 467 residues long.
MolForge cross-references it against 0 known binders and
353 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit gamma-3 |
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| UniProt accession | Q99928 |
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| Gene | GABRG3 |
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| Organism | Homo sapiens |
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| Length | 467 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (353)
Diseases linked to this target (Open Targets).
- unipolar depression · score 0.61
- epilepsy · score 0.61
- insomnia · score 0.60
- Agitation · score 0.60
- panic disorder · score 0.60
- pain · score 0.60
- anxiety disorder · score 0.60
- alcohol dependence · score 0.60
- anxiety · score 0.60
- delirium · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99928-F1 | alphafold | PREDICTED | 75.23 | — |
Amino-acid sequence (467 residues)
MAPKLLLLLC LFSGLHARSR KVEEDEYEDS SSNQKWVLAP KSQDTDVTLI LNKLLREYDK KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ TWTDSRLRFN STMKILTLNS NMVGLIWIPD TIFRNSKTAE AHWITTPNQL LRIWNDGKIL YTLRLTINAE CQLQLHNFPM DEHSCPLIFS SYGYPKEEMI YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY VVMTIYFELS RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTALGI TTVLTMTTLS TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTTTK KTTSLLHPDS SRWIPERISL QAPSNYSLLD MRPPPTAMIT LNNSVYWQEF EDTCVYECLD GKDCQSFFCC YEECKSGSWR KGRIHIDILE LDSYSRVFFP TSFLLFNLVY WVGYLYL
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