Achaete-scute homolog 2 (ASCL2)

About Achaete-scute homolog 2

Achaete-scute homolog 2 (ASCL2) is a protein from Homo sapiens identified by UniProt accession Q99929, 193 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	Achaete-scute homolog 2
UniProt accession	Q99929
Gene	ASCL2
Organism	Homo sapiens
Length	193 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.34
HbA1c measurement · score 0.28
Eczematoid dermatitis · score 0.28
allergic rhinitis · score 0.18
neurodegenerative disease · score 0.14
prostate carcinoma · score 0.11
neoplasm · score 0.10
leukocyte count · score 0.10
colorectal carcinoma · score 0.09
blood protein measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99929-F1	alphafold	PREDICTED	70.76	—

Amino-acid sequence (193 residues)

MDGGTLPRSA PPAPPVPVGC AARRRPASPE LLRCSRRRRP ATAETGGGAA AVARRNERER NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL RPQAVRPSAP RGPPGTTPVA ASPSRASSSP GRGGSSEPGS PRSAYSSDDS GCEGALSPAE RELLDFSSWL GGY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards