About Sperm-associated antigen 8
Sperm-associated antigen 8 (SPAG8) is a protein
from Homo sapiens identified by UniProt accession
Q99932, 485 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Sperm-associated antigen 8 |
|---|
| UniProt accession | Q99932 |
|---|
| Gene | SPAG8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 485 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- Acromesomelic dysplasia, Maroteaux type · score 0.54
- acromesomelic dysplasia 1, Maroteaux type · score 0.54
- tall stature-scoliosis-macrodactyly of the great toes syndrome · score 0.53
- Tall stature - scoliosis - macrodactyly of the great toes · score 0.53
- familial focal epilepsy with variable foci · score 0.37
- genetic disorder · score 0.17
- body height · score 0.09
- heel bone mineral density · score 0.08
- serum gamma-glutamyl transferase measurement · score 0.05
- Red cell distribution width · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99932-F1 | alphafold | PREDICTED | 56.70 | — |
Amino-acid sequence (485 residues)
METNESTEGS RSRSRSLDIQ PSSEGLGPTS EPFPSSDDSP RSALAAATAA AAAAASAAAA TAAFTTAKAA ALSTKTPAPC SEFMEPSSDP SLLGEPCAGP GFTHNIAHGS LGFEPVYVSC IAQDTCTTTD HSSNPGPVPG SSSGPVLGSS SGAGHGSGSG SGPGCGSVPG SGSGPGPGSG PGSGPGHGSG SHPGPASGPG PDTGPDSELS PCIPPGFRNL VADRVPNYTS WSQHCPWEPQ KQPPWEFLQV LEPGARGLWK PPDIKGKLMV CYETLPRGQC LLYNWEEERA TNHLDQVPSM QDGSESFFFR HGHRGLLTMQ LKSPMPSSTT QKDSYQPPGN VYWPLRGKRE AMLEMLLQHQ ICKEVQAEQE PTRKLFEVES VTHHDYRMEL AQAGTPAPTK PHDYRQEQPE TFWIQRAPQL PGVSNIRTLD TPFRKNCSFS TPVPLSLGKL LPYEPENYPY QLGEISSLPC PGGRLGGGGG RMTPF
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