BAG family molecular chaperone regulator 1 (BAG1)

About BAG family molecular chaperone regulator 1

BAG family molecular chaperone regulator 1 (BAG1) is a protein from Homo sapiens identified by UniProt accession Q99933, 345 residues long. MolForge cross-references it against 0 known binders and 204 disease associations.

Target properties

Protein name	BAG family molecular chaperone regulator 1
UniProt accession	Q99933
Gene	BAG1
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (204)

Diseases linked to this target (Open Targets).

glucose measurement · score 0.11
neoplasm · score 0.10
non-small cell lung carcinoma · score 0.09
Blackfan-Diamond anemia · score 0.09
cyst · score 0.08
electrocardiography · score 0.08
squamous cell carcinoma · score 0.08
melanoma · score 0.07
gallbladder carcinoma · score 0.07
nail-patella syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99933-F1	alphafold	PREDICTED	62.68	—

Amino-acid sequence (345 residues)

MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR STASGHDRPT RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW SEEATQSEEA TQGEEMNRSQ EVTRDEESTR SEEVTREEMA AAGLTVTVTH SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV IGVPQSFQKL IFKGKSLKEM ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV EKIADQLEEL NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN FKDSRLKRKG LVKKVQAFLA ECDTVEQNIC QETERLQSTN FALAE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards