About Cyclic AMP-dependent transcription factor ATF-6 beta
Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B) is a protein
from Homo sapiens identified by UniProt accession
Q99941, 703 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Cyclic AMP-dependent transcription factor ATF-6 beta |
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| UniProt accession | Q99941 |
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| Gene | ATF6B |
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| Organism | Homo sapiens |
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| Length | 703 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- blood protein measurement · score 0.13
- complement C4 measurement · score 0.09
- self reported educational attainment · score 0.08
- Ichthyosis-hypotrichosis syndrome · score 0.05
- peeling skin syndrome · score 0.05
- acral peeling skin syndrome · score 0.04
- BMI-adjusted waist-hip ratio · score 0.04
- physical activity measurement · score 0.04
- systolic blood pressure · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99941-F1 | alphafold | PREDICTED | 54.29 | — |
Amino-acid sequence (703 residues)
MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL SSESSRLSTE PSSEALGVGE VLHVKTESLA PPLCLLGDDP TSSFETVQIN VIPTSDDSSD VQTKIEPVSP CSSVNSEASL LSADSSSQAF IGEEVLEVKT ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR KPPLQPKPVV LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL QGLEARLQAV LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRKVVCI MVFLLFIAFN FGPVSISEPP SAPISPRMNK GEPQPRRHLL GFSEQEPVQG VEPLQGSSQG PKEPQPSPTD QPSFSNLTAF PGGAKELLLR DLDQLFLSSD CRHFNRTESL RLADELSGWV QRHQRGRRKI PQRAQERQKS QPRKKSPPVK AVPIQPPGPP ERDSVGQLQL YRHPDRSQPA FLDAIDRRED TFYVVSFRRD HLLLPAISHN KTSRPKMSLV MPAMAPNETL SGRGAPGDYE EMMQIECEVM DTRVIHIKTS TVPPSLRKQP SPTPGNATGG PLPVSAASQA HQASHQPLYL NHP
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