E3 ubiquitin-protein ligase RNF5 (RNF5)

About E3 ubiquitin-protein ligase RNF5

E3 ubiquitin-protein ligase RNF5 (RNF5) is a protein from Homo sapiens identified by UniProt accession Q99942, 180 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF5
UniProt accession	Q99942
Gene	RNF5
Organism	Homo sapiens
Length	180 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

cystic fibrosis · score 0.48
sRAGE measurement · score 0.22
waist circumference · score 0.19
serum alanine aminotransferase measurement · score 0.11
neoplasm · score 0.10
response to clozapine · score 0.10
Drug-induced agranulocytosis · score 0.10
FEV/FVC ratio · score 0.09
body mass index · score 0.08
hip circumference · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99942-F1	alphafold	PREDICTED	67.54	—

Amino-acid sequence (180 residues)

MAAAEEEDGG PEGPNRERGG AGATFECNIC LETAREAVVS VCGHLYCWPC LHQWLETRPE RQECPVCKAG ISREKVVPLY GRGSQKPQDP RLKTPPRPQG QRPAPESRGG FQPFGDTGGF HFSFGVGAFP FGFFTTVFNA HEPFRRGTGV DLGQGHPASS WQDSLFLFLA IFFFFWLLSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards