Epidermal growth factor-like protein 8 (EGFL8)

About Epidermal growth factor-like protein 8

Epidermal growth factor-like protein 8 (EGFL8) is a protein from Homo sapiens identified by UniProt accession Q99944, 293 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Epidermal growth factor-like protein 8
UniProt accession	Q99944
Gene	EGFL8
Organism	Homo sapiens
Length	293 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

psoriasis · score 0.57
neurodegenerative disease · score 0.53
inflammatory skin disease · score 0.19
total blood protein measurement · score 0.11
waist circumference · score 0.09
hepatocellular carcinoma · score 0.07
pulse pressure measurement · score 0.06
neoplasm · score 0.06
FEV/FVC ratio · score 0.05
birth weight · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99944-F1	alphafold	PREDICTED	75.72	—

Amino-acid sequence (293 residues)

MGSRAELCTL LGGFSFLLLL IPGEGAKGGS LRESQGVCSK QTLVVPLHYN ESYSQPVYKP YLTLCAGRRI CSTYRTMYRV MWREVRREVQ QTHAVCCQGW KKRHPGALTC EAICAKPCLN GGVCVRPDQC ECAPGWGGKH CHVDVDECRT SITLCSHHCF NTAGSFTCGC PHDLVLGVDG RTCMEGSPEP PTSASILSVA VREAEKDERA LKQEIHELRG RLERLEQWAG QAGAWVRAVL PVPPEELQPE QVAELWGRGD RIESLSDQVL LLEERLGACS CEDNSLGLGV NHR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards