Proline-rich transmembrane protein 1 (PRRT1)

About Proline-rich transmembrane protein 1

Proline-rich transmembrane protein 1 (PRRT1) is a protein from Homo sapiens identified by UniProt accession Q99946, 306 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Proline-rich transmembrane protein 1
UniProt accession	Q99946
Gene	PRRT1
Organism	Homo sapiens
Length	306 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

total blood protein measurement · score 0.16
phospholipid measurement · score 0.09
risk-taking behaviour · score 0.09
serum IgG glycosylation measurement · score 0.09
specific language impairment · score 0.08
7q11.23 microduplication syndrome · score 0.07
Monoamine oxidase A deficiency · score 0.06
microangiopathy and leukoencephalopathy, pontine, autosomal dominant · score 0.06
blood protein measurement · score 0.06
schizophrenia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99946-F1	alphafold	PREDICTED	52.95	—

Amino-acid sequence (306 residues)

MSSEKSGLPD SVPHTSPPPY NAPQPPAEPP APPPQAAPSS HHHHHHHYHQ SGTATLPRLG AGGLASSAAT AQRGPSSSAT LPRPPHHAPP GPAAGAPPPG CATLPRMPPD PYLQETRFEG PLPPPPPAAA APPPPAPAQT AQAPGFVVPT HAGTVGTLPL GGYVAPGYPL QLQPCTAYVP VYPVGTPYAG GTPGGTGVTS TLPPPPQGPG LALLEPRRPP HDYMPIAVLT TICCFWPTGI IAIFKAVQVR TALARGDMVS AEIASREARN FSFISLAVGI AAMVLCTILT VVIIIAAQHH ENYWDP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards