About Dual specificity protein phosphatase 9
Dual specificity protein phosphatase 9 (DUSP9) is a protein
from Homo sapiens identified by UniProt accession
Q99956, 384 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Dual specificity protein phosphatase 9 |
|---|
| UniProt accession | Q99956 |
|---|
| Gene | DUSP9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 384 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- breast adenocarcinoma · score 0.29
- type 2 diabetes mellitus · score 0.27
- diabetes mellitus · score 0.26
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.18
- complication · score 0.18
- hepatocellular carcinoma · score 0.10
- nonpapillary renal cell carcinoma · score 0.09
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99956-F1 | alphafold | PREDICTED | 75.65 | — |
Amino-acid sequence (384 residues)
MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGSLCLGSD CSDAESEADR DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA SAASNPPSFF TTPTSDGAFE LAPT
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