Forkhead box protein C2 (FOXC2)

About Forkhead box protein C2

Forkhead box protein C2 (FOXC2) is a protein from Homo sapiens identified by UniProt accession Q99958, 501 residues long. MolForge cross-references it against 0 known binders and 372 disease associations.

Target properties

Protein name	Forkhead box protein C2
UniProt accession	Q99958
Gene	FOXC2
Organism	Homo sapiens
Length	501 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (372)

Diseases linked to this target (Open Targets).

lymphedema-distichiasis syndrome · score 0.82
Lymphedema - distichiasis · score 0.75
genetic disorder · score 0.41
hydrops fetalis · score 0.38
Cleft palate · score 0.38
cleft palate · score 0.37
neuroinflammatory disorder · score 0.37
neurodegenerative disease · score 0.37
heel bone mineral density · score 0.35
bone density · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99958-F1	alphafold	PREDICTED	55.16	—

Amino-acid sequence (501 residues)

MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYSA GMGRSYAPYH HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI RHNLSLNECF VKVPRDDKKP GKGSYWTLDP DSYNMFENGS FLRRRRRFKK KDVSKEKEER AHLKEPPPAA SKGAPATPHL ADAPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS PRSAASTPAG SPDGSLPEHH AAAPNGLPGF SVENIMTLRT SPPGGELSPG AGRAGLVVPP LALPYAAAPP AAYGQPCAQG LEAGAAGGYQ CSMRAMSLYT GAERPAHMCV PPALDEALSD HPSGPTSPLS ALNLAAGQEG ALAATGHHHQ HHGHHHPQAP PPPPAPQPQP TPQPGAAAAQ AASWYLNHSG DLNHLPGHTF AAQQQTFPNV REMFNSHRLG IENSTLGESQ VSGNASCQLP YRSTPPLYRH AAPYSYDCTK Y

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards