About Plakophilin-2
Plakophilin-2 (PKP2) is a protein
from Homo sapiens identified by UniProt accession
Q99959, 881 residues long.
MolForge cross-references it against 0 known binders and
183 disease associations.
Target properties
| Protein name | Plakophilin-2 |
|---|
| UniProt accession | Q99959 |
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| Gene | PKP2 |
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| Organism | Homo sapiens |
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| Length | 881 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (183)
Diseases linked to this target (Open Targets).
- Arrhythmogenic right ventricular dysplasia · score 0.82
- arrhythmogenic right ventricular cardiomyopathy · score 0.76
- cardiomyopathy · score 0.58
- Abnormality of the cardiovascular system · score 0.56
- familial isolated arrhythmogenic right ventricular dysplasia · score 0.54
- cardiac arrhythmia · score 0.48
- left ventricular noncompaction · score 0.48
- atrial fibrillation · score 0.46
- ventricular tachycardia · score 0.43
- familial isolated arrhythmogenic ventricular dysplasia, left dominant form · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99959-F1 | alphafold | PREDICTED | 64.13 | — |
Amino-acid sequence (881 residues)
MAAPGAPAEY GYIRTVLGQQ ILGQLDSSSL ALPSEAKLKL AGSSGRGGQT VKSLRIQEQV QQTLARKGRS SVGNGNLHRT SSVPEYVYNL HLVENDFVGG RSPVPKTYDM LKAGTTATYE GRWGRGTAQY SSQKSVEERS LRHPLRRLEI SPDSSPERAH YTHSDYQYSQ RSQAGHTLHH QESRRAALLV PPRYARSEIV GVSRAGTTSR QRHFDTYHRQ YQHGSVSDTV FDSIPANPAL LTYPRPGTSR SMGNLLEKEN YLTAGLTVGQ VRPLVPLQPV TQNRASRSSW HQSSFHSTRT LREAGPSVAV DSSGRRAHLT VGQAAAGGSG NLLTERSTFT DSQLGNADME MTLERAVSML EADHMLPSRI SAAATFIQHE CFQKSEARKR VNQLRGILKL LQLLKVQNED VQRAVCGALR NLVFEDNDNK LEVAELNGVP RLLQVLKQTR DLETKKQITD HTVNLRSRNG WPGAVAHACN PSTLGGQGGR ITRSGVRDQP DQHGLLWNLS SNDKLKNLMI TEALLTLTEN IIIPFSGWPE GDYPKANGLL DFDIFYNVTG CLRNMSSAGA DGRKAMRRCD GLIDSLVHYV RGTIADYQPD DKATENCVCI LHNLSYQLEA ELPEKYSQNI YIQNRNIQTD NNKSIGCFGS RSRKVKEQYQ DVPMPEEKSN PKGVEWLWHS IVIRMYLSLI AKSVRNYTQE ASLGALQNLT AGSGPMPTSV AQTVVQKESG LQHTRKMLHV GDPSVKKTAI SLLRNLSRNL SLQNEIAKET LPDLVSIIPD TVPSTDLLIE TTASACYTLN NIIQNSYQNA RDLLNTGGIQ KIMAISAGDA YASNKASKAA SVLLYSLWAH TELHHAYKKA QFKKTDFVNS RTAKAYHSLK D
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