Endophilin-A2 (SH3GL1)

About Endophilin-A2

Endophilin-A2 (SH3GL1) is a protein from Homo sapiens identified by UniProt accession Q99961, 368 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Endophilin-A2
UniProt accession	Q99961
Gene	SH3GL1
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

listeriosis · score 0.46
lymphoid neoplasm · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
breast ductal adenocarcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
clear cell renal carcinoma · score 0.32
head and neck squamous cell carcinoma · score 0.32
acute myeloid leukemia · score 0.28
hepatocellular carcinoma · score 0.28
esophageal adenocarcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99961-F1	alphafold	PREDICTED	83.89	—

Amino-acid sequence (368 residues)

MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV LARTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF EESKEVAETS MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL KRRMREASSR PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG QSGFFPLSYV EVLVPLPQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards