About Endophilin-A3
Endophilin-A3 (SH3GL3) is a protein
from Homo sapiens identified by UniProt accession
Q99963, 347 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Endophilin-A3 |
|---|
| UniProt accession | Q99963 |
|---|
| Gene | SH3GL3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 347 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (59)
Diseases linked to this target (Open Targets).
- listeriosis · score 0.46
- protein measurement · score 0.34
- forced expiratory volume · score 0.33
- chronic obstructive pulmonary disease · score 0.33
- diffuse plaque measurement · score 0.29
- smoking status measurement · score 0.29
- glioblastoma multiforme · score 0.28
- FEV/FVC ratio · score 0.28
- body height · score 0.28
- lung adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99963-F1 | alphafold | PREDICTED | 88.32 | — |
Amino-acid sequence (347 residues)
MSVAGLKKQF HKASQLFSEK ISGAEGTKLD DEFLDMERKI DVTNKVVAEI LSKTTEYLQP NPAYRAKLGM LNTVSKIRGQ VKTTGYPQTE GLLGDCMLKY GKELGEDSTF GNALIEVGES MKLMAEVKDS LDINVKQTFI DPLQLLQDKD LKEIGHHLKK LEGRRLDYDY KKKRVGKIPD EEVRQAVEKF EESKELAERS MFNFLENDVE QVSQLAVFIE AALDYHRQST EILQELQSKL QMRISAASSV PRREYKPRPV KRSSSELNGV STTSVVKTTG SNIPMDQPCC RGLYDFEPEN QGELGFKEGD IITLTNQIDE NWYEGMIHGE SGFFPINYVE VIVPLPQ
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