About Disintegrin and metalloproteinase domain-containing protein 2
Disintegrin and metalloproteinase domain-containing protein 2 (ADAM2) is a protein
from Homo sapiens identified by UniProt accession
Q99965, 735 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Disintegrin and metalloproteinase domain-containing protein 2 |
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| UniProt accession | Q99965 |
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| Gene | ADAM2 |
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| Organism | Homo sapiens |
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| Length | 735 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (51)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- lung adenocarcinoma · score 0.26
- cutaneous melanoma · score 0.25
- squamous cell lung carcinoma · score 0.18
- breast adenocarcinoma · score 0.16
- glioblastoma multiforme · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- neoplasm · score 0.08
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99965-F1 | alphafold | PREDICTED | 81.42 | — |
Amino-acid sequence (735 residues)
MWRVLFLLSG LGGLRMDSNF DSLPVQITVP EKIRSIIKEG IESQASYKIV IEGKPYTVNL MQKNFLPHNF RVYSYSGTGI MKPLDQDFQN FCHYQGYIEG YPKSVVMVST CTGLRGVLQF ENVSYGIEPL ESSVGFEHVI YQVKHKKADV SLYNEKDIES RDLSFKLQSV EPQQDFAKYI EMHVIVEKQL YNHMGSDTTV VAQKVFQLIG LTNAIFVSFN ITIILSSLEL WIDENKIATT GEANELLHTF LRWKTSYLVL RPHDVAFLLV YREKSNYVGA TFQGKMCDAN YAGGVVLHPR TISLESLAVI LAQLLSLSMG ITYDDINKCQ CSGAVCIMNP EAIHFSGVKI FSNCSFEDFA HFISKQKSQC LHNQPRLDPF FKQQAVCGNA KLEAGEECDC GTEQDCALIG ETCCDIATCR FKAGSNCAEG PCCENCLFMS KERMCRPSFE ECDLPEYCNG SSASCPENHY VQTGHPCGLN QWICIDGVCM SGDKQCTDTF GKEVEFGPSE CYSHLNSKTD VSGNCGISDS GYTQCEADNL QCGKLICKYV GKFLLQIPRA TIIYANISGH LCIAVEFASD HADSQKMWIK DGTSCGSNKV CRNQRCVSSS YLGYDCTTDK CNDRGVCNNK KHCHCSASYL PPDCSVQSDL WPGGSIDSGN FPPVAIPARL PERRYIENIY HSKPMRWPFF LFIPFFIIFC VLIAIMVKVN FQRKKWRTED YSSDEQPESE SEPKG
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