Cbp/p300-interacting transactivator 2 (CITED2)

About Cbp/p300-interacting transactivator 2

Cbp/p300-interacting transactivator 2 (CITED2) is a protein from Homo sapiens identified by UniProt accession Q99967, 270 residues long. MolForge cross-references it against 0 known binders and 311 disease associations.

Target properties

Protein name	Cbp/p300-interacting transactivator 2
UniProt accession	Q99967
Gene	CITED2
Organism	Homo sapiens
Length	270 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (311)

Diseases linked to this target (Open Targets).

atrial septal defect 8 · score 0.52
mean corpuscular volume · score 0.50
mean corpuscular hemoglobin concentration · score 0.48
mean reticulocyte volume · score 0.47
ventricular septal defect 2 · score 0.47
reticulocyte count · score 0.45
mean corpuscular hemoglobin · score 0.42
Immature Reticulocyte Fraction Measurement · score 0.42
erythrocyte count · score 0.39
high density lipoprotein cholesterol measurement · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99967-F1	alphafold	PREDICTED	51.48	—

Amino-acid sequence (270 residues)

MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards