Myocilin (MYOC)

About Myocilin

Myocilin (MYOC) is a protein from Homo sapiens identified by UniProt accession Q99972, 504 residues long. MolForge cross-references it against 0 known binders and 147 disease associations.

Target properties

Protein name	Myocilin
UniProt accession	Q99972
Gene	MYOC
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (147)

Diseases linked to this target (Open Targets).

glaucoma 1, open angle, A · score 0.83
Juvenile glaucoma · score 0.83
glaucoma · score 0.68
juvenile open angle glaucoma · score 0.67
open-angle glaucoma · score 0.65
platelet component distribution width · score 0.50
congenital glaucoma · score 0.38
intraocular pressure measurement · score 0.37
response to xenobiotic stimulus · score 0.31
Abnormality of T cell physiology · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99972-F1	alphafold	PREDICTED	78.92	—

Amino-acid sequence (504 residues)

MRFFCARCCS FGPEMPAVQL LLLACLVWDV GARTAQLRKA NDQSGRCQYT FSVASPNESS CPEQSQAMSV IHNLQRDSST QRLDLEATKA RLSSLESLLH QLTLDQAARP QETQEGLQRE LGTLRRERDQ LETQTRELET AYSNLLRDKS VLEEEKKRLR QENENLARRL ESSSQEVARL RRGQCPQTRD TARAVPPGSR EVSTWNLDTL AFQELKSELT EVPASRILKE SPSGYLRSGE GDTGCGELVW VGEPLTLRTA ETITGKYGVW MRDPKPTYPY TQETTWRIDT VGTDVRQVFE YDLISQFMQG YPSKVHILPR PLESTGAVVY SGSLYFQGAE SRTVIRYELN TETVKAEKEI PGAGYHGQFP YSWGGYTDID LAVDEAGLWV IYSTDEAKGA IVLSKLNPEN LELEQTWETN IRKQSVANAF IICGTLYTVS SYTSADATVN FAYDTGTGIS KTLTIPFKNR YKYSSMIDYN PLEKKLFAWD NLNMVTYDIK LSKM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards