Serine/threonine-protein kinase VRK1 (VRK1)

About Serine/threonine-protein kinase VRK1

Serine/threonine-protein kinase VRK1 (VRK1) is a protein from Homo sapiens identified by UniProt accession Q99986, 396 residues long. MolForge cross-references it against 0 known binders and 266 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase VRK1
UniProt accession	Q99986
Gene	VRK1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99986-F1	alphafold	PREDICTED	85.01	—

Amino-acid sequence (396 residues)

MPRVKAAQAG RQSSAKRHLA EQFAVGEIIT DMAKKEWKVG LPIGQGGFGC IYLADMNSSE SVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTRKLKYLGV PKYWGSGLHD KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA SNLLLNYKNP DQVYLVDYGL AYRYCPEGVH KEYKEDPKRC HDGTIEFTSI DAHNGVAPSR RGDLEILGYC MIQWLTGHLP WEDNLKDPKY VRDSKIRYRE NIASLMDKCF PEKNKPGEIA KYMETVKLLD YTEKPLYENL RDILLQGLKA IGSKDDGKLD LSVVENGGLK AKTITKKRKK EIEESKEPGV EDTEWSNTQT EEAIQTRSRT RKRVQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards