About Transcription cofactor vestigial-like protein 1
Transcription cofactor vestigial-like protein 1 (VGLL1) is a protein
from Homo sapiens identified by UniProt accession
Q99990, 258 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Transcription cofactor vestigial-like protein 1 |
|---|
| UniProt accession | Q99990 |
|---|
| Gene | VGLL1 |
|---|
| Organism | Homo sapiens |
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| Length | 258 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.10
- cancer · score 0.09
- COVID-19 · score 0.02
- chronic interstitial cystitis · score 0.01
- breast carcinoma · score 0.01
- carcinoma · score 0.01
- urinary bladder carcinoma · score 0.01
- myoepithelial tumor · score 0.01
- chronic obstructive pulmonary disease · score 0.00
- triple-negative breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99990-F1 | alphafold | PREDICTED | 57.33 | — |
Amino-acid sequence (258 residues)
MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS NIKSPQELTP SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA NCNLHVPGPM AVNQFSPSLA RRASVRPGEL WHFSSLAGTS SLEPGYSHPF PARHLVPEPQ PDGKREPLLS LLQQDRCLAR PQESAARENG NPGQIAGSTG LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY SLTPPNHWGH PHRYLQHL
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