About Dihydropyrimidinase-related protein 5
Dihydropyrimidinase-related protein 5 (DPYSL5) is a protein
from Homo sapiens identified by UniProt accession
Q9BPU6, 564 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | Dihydropyrimidinase-related protein 5 |
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| UniProt accession | Q9BPU6 |
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| Gene | DPYSL5 |
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| Organism | Homo sapiens |
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| Length | 564 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (161)
Diseases linked to this target (Open Targets).
- Ritscher-Schinzel syndrome 4 · score 0.54
- 3C syndrome · score 0.37
- complex neurodevelopmental disorder · score 0.37
- neurodegenerative disease · score 0.33
- electrocardiography · score 0.24
- glucose measurement · score 0.20
- body mass index · score 0.19
- cortical thickness · score 0.19
- genetic disorder · score 0.18
- IGF-1 measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BPU6-F1 | alphafold | PREDICTED | 91.00 | — |
Amino-acid sequence (564 residues)
MLANSASVRI LIKGGKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV IDATGKLVIP GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH VLPDKETSLV DAYEKCRGLA DPKVCCDYAL HVGITWWAPK VKAEMETLVR EKGVNSFQMF MTYKDLYMLR DSELYQVLHA CKDIGAIARV HAENGELVAE GAKEALDLGI TGPEGIEISR PEELEAEATH RVITIANRTH CPIYLVNVSS ISAGDVIAAA KMQGKVVLAE TTTAHATLTG LHYYHQDWSH AAAYVTVPPL RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG VQDRMSVIWE RGVVGGKMDE NRFVAVTSSN AAKLLNLYPR KGRIIPGADA DVVVWDPEAT KTISASTQVQ GGDFNLYENM RCHGVPLVTI SRGRVVYENG VFMCAEGTGK FCPLRSFPDT VYKKLVQREK TLKVRGVDRT PYLGDVAVVV HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI DDHVPKRASA RILAPPGGRS SGIW
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