About Apolipoprotein L4
Apolipoprotein L4 (APOL4) is a protein
from Homo sapiens identified by UniProt accession
Q9BPW4, 351 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Apolipoprotein L4 |
|---|
| UniProt accession | Q9BPW4 |
|---|
| Gene | APOL4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 351 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- chronic kidney disease · score 0.12
- platelet count · score 0.06
- type 2 diabetes mellitus · score 0.05
- diabetic nephropathy · score 0.05
- FEV/FVC ratio · score 0.04
- central nervous system cancer · score 0.04
- glioblastoma multiforme · score 0.03
- Leishmaniasis · score 0.03
- reticulocyte measurement · score 0.03
- hematocrit · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BPW4-F1 | alphafold | PREDICTED | 52.71 | — |
Amino-acid sequence (351 residues)
MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV HLKILLTSDE AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK EQQFREWFLK EFPQIRWKIQ ESIERLRVIA NEIEKVHRGC VIANVVSGST GILSVIGVML APFTAGLSLS ITAAGVGLGI ASATAGIASS IVENTYTRSA ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT KMIANDVHTL RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA G
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