About Polyadenylate-binding protein-interacting protein 2
Polyadenylate-binding protein-interacting protein 2 (PAIP2) is a protein
from Homo sapiens identified by UniProt accession
Q9BPZ3, 127 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Polyadenylate-binding protein-interacting protein 2 |
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| UniProt accession | Q9BPZ3 |
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| Gene | PAIP2 |
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| Organism | Homo sapiens |
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| Length | 127 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- azoospermia · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failures 50 · score 0.05
- spermatogenic failure 61 · score 0.05
- spermatogenic failure 59 · score 0.05
- spermatogenic failure 73 · score 0.05
- spermatogenic failure 74 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BPZ3-F1 | alphafold | PREDICTED | 70.81 | — |
Amino-acid sequence (127 residues)
MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI
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