About Target of rapamycin complex 2 subunit MAPKAP1
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) is a protein
from Homo sapiens identified by UniProt accession
Q9BPZ7, 522 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | Target of rapamycin complex 2 subunit MAPKAP1 |
|---|
| UniProt accession | Q9BPZ7 |
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| Gene | MAPKAP1 |
|---|
| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (149)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- lysosomal storage disease · score 0.37
- breast adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- endometrial cancer · score 0.28
- systolic blood pressure · score 0.26
- diastolic blood pressure · score 0.26
- lung adenocarcinoma · score 0.25
- body height · score 0.25
- physical activity measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BPZ7-F1 | alphafold | PREDICTED | 69.22 | — |
Amino-acid sequence (522 residues)
MAFLDNPTII LAHIRQSHVT SDDTGMCEMV LIDHDVDLEK IHPPSMPGDS GSEIQGSNGE TQGYVYAQSV DITSSWDFGI RRRSNTAQRL ERLRKERQNQ IKCKNIQWKE RNSKQSAQEL KSLFEKKSLK EKPPISGKQS ILSVRLEQCP LQLNNPFNEY SKFDGKGHVG TTATKKIDVY LPLHSSQDRL LPMTVVTMAS ARVQDLIGLI CWQYTSEGRE PKLNDNVSAY CLHIAEDDGE VDTDFPPLDS NEPIHKFGFS TLALVEKYSS PGLTSKESLF VRINAAHGFS LIQVDNTKVT MKEILLKAVK RRKGSQKVSG PQYRLEKQSE PNVAVDLDST LESQSAWEFC LVRENSSRAD GVFEEDSQID IATVQDMLSS HHYKSFKVSM IHRLRFTTDV QLGISGDKVE IDPVTNQKAS TKFWIKQKPI SIDSDLLCAC DLAEEKSPSH AIFKLTYLSN HDYKHLYFES DAATVNEIVL KVNYILESRA STARADYFAQ KQRKLNRRTS FSFQKEKKSG QQ
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