RNA-binding protein 4B (RBM4B)

About RNA-binding protein 4B

RNA-binding protein 4B (RBM4B) is a protein from Homo sapiens identified by UniProt accession Q9BQ04, 359 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	RNA-binding protein 4B
UniProt accession	Q9BQ04
Gene	RBM4B
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

MODY · score 0.09
chronic pancreatitis · score 0.05
diabetes mellitus, transient neonatal, 2 · score 0.05
type 1 diabetes mellitus · score 0.05
type 2 diabetes mellitus · score 0.05
exercise-induced hyperinsulinism · score 0.05
hyperinsulinemic hypoglycemia, familial, 2 · score 0.05
hyperproinsulinemia · score 0.05
histidinemia · score 0.04
hyperinsulinism due to glucokinase deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQ04-F1	alphafold	PREDICTED	64.40	—

Amino-acid sequence (359 residues)

MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPVDRT GRVADFTEQY NEQYGAVRTP YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA YNYAEQTMSH LPQVQSTTVT SHLNSTSVDP YDRHLLPNSG AAATSAAMAA AAATTSSYYG RDRSPLRRAA AMLPTVGEGY GYGPESELSQ ASAATRNSLY DMARYEREQY VDRARYSAF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards