Zinc finger FYVE domain-containing protein 21…

About Zinc finger FYVE domain-containing protein 21

Zinc finger FYVE domain-containing protein 21 (ZFYVE21) is a protein from Homo sapiens identified by UniProt accession Q9BQ24, 234 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Zinc finger FYVE domain-containing protein 21
UniProt accession	Q9BQ24
Gene	ZFYVE21
Organism	Homo sapiens
Length	234 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.23
sex hormone-binding globulin measurement · score 0.23
Premature coronary artery atherosclerosis · score 0.12
physical activity · score 0.09
body mass index · score 0.08
multisite chronic pain · score 0.07
hemoglobin measurement · score 0.07
PHF-tau measurement · score 0.07
schizophrenia · score 0.06
vitamin D measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQ24-F1	alphafold	PREDICTED	91.01	—

Amino-acid sequence (234 residues)

MSSEVSARRD AKKLVRSPSG LRMVPEHRAF GSPFGLEEPQ WVPDKECRRC MQCDAKFDFL TRKHHCRRCG KCFCDRCCSQ KVPLRRMCFV DPVRQCAECA LVSLKEAEFY DKQLKVLLSG ATFLVTFGNS EKPETMTCRL SNNQRYLFLD GDSHYEIEIV HISTVQILTE GFPPGGGNAR ATGMFLQYTV PGTEGVTQLK LTVVEDVTVG RRQAVAWLVA MHKAAKLLYE SRDQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Zinc finger FYVE domain-containing protein 21 (ZFYVE21)