About Delayed-rectifier potassium channel regulatory subunit KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3 (KCNS3) is a protein
from Homo sapiens identified by UniProt accession
Q9BQ31, 491 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Delayed-rectifier potassium channel regulatory subunit KCNS3 |
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| UniProt accession | Q9BQ31 |
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| Gene | KCNS3 |
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| Organism | Homo sapiens |
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| Length | 491 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- FEV/FVC ratio · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- forced expiratory volume · score 0.42
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
- transverse myelitis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQ31-F1 | alphafold | PREDICTED | 78.62 | — |
Amino-acid sequence (491 residues)
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSNR YQERKEENHE KDWDQKSHDV STDSSFEESS LFEKELEKFD TLRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR LAAAPCQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH TSSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL PITIIFNKFS KYYQKQKDID VDQCSEDAPE KCHELPYFNI RDIYAQRMHT FITSLSSVGI VVSDPDSTDA SSIEDNEDIC NTTSLENCTA K
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