About U6 snRNA phosphodiesterase 1
U6 snRNA phosphodiesterase 1 (USB1) is a protein
from Homo sapiens identified by UniProt accession
Q9BQ65, 265 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | U6 snRNA phosphodiesterase 1 |
|---|
| UniProt accession | Q9BQ65 |
|---|
| Gene | USB1 |
|---|
| Organism | Homo sapiens |
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| Length | 265 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- poikiloderma with neutropenia · score 0.77
- dyskeratosis congenita · score 0.46
- eosinophil count · score 0.23
- eosinophil percentage of leukocytes · score 0.22
- genetic disorder · score 0.19
- Hematuria · score 0.09
- body fat percentage · score 0.06
- serum alanine aminotransferase measurement · score 0.05
- FEV/FVC ratio · score 0.05
- high density lipoprotein cholesterol measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQ65-F1 | alphafold | PREDICTED | 82.95 | — |
Amino-acid sequence (265 residues)
MSAAPLVGYS SSGSEDESED GMRTRPGDGS HRRGQSPLPR QRFPVPDSVL NMFPGTEEGP EDDSTKHGGR VRTFPHERGN WATHVYVPYE AKEEFLDLLD VLLPHAQTYV PRLVRMKVFH LSLSQSVVLR HHWILPFVQA LKARMTSFHR FFFTANQVKI YTNQEKTRTF IGLEVTSGHA QFLDLVSEVD RVMEEFNLTT FYQDPSFHLS LAWCVGDARL QLEGQCLQEL QAIVDGFEDA EVLLRVHTEQ VRCKSGNKFF SMPLK
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