Glutamate-rich WD repeat-containing protein 1 (GRWD1)

About Glutamate-rich WD repeat-containing protein 1

Glutamate-rich WD repeat-containing protein 1 (GRWD1) is a protein from Homo sapiens identified by UniProt accession Q9BQ67, 446 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Glutamate-rich WD repeat-containing protein 1
UniProt accession	Q9BQ67
Gene	GRWD1
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
colon carcinoma · score 0.07
neoplasm · score 0.07
cancer · score 0.07
triple-negative breast cancer · score 0.05
lung adenocarcinoma · score 0.02
non-small cell lung carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQ67-F1	alphafold	PREDICTED	88.81	—

Amino-acid sequence (446 residues)

MAARKGRRRT CETGEPMEAE SGDTSSEGPA QVYLPGRGPP LREGEELVMD EEAYVLYHRA QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESAQS NRLMMLRMHN LHGTKPPPSE GSDEEEEEED EEDEEERKPQ LELAMVPHYG GINRVRVSWL GEEPVAGVWS EKGQVEVFAL RRLLQVVEEP QALAAFLRDE QAQMKPIFSF AGHMGEGFAL DWSPRVTGRL LTGDCQKNIH LWTPTDGGSW HVDQRPFVGH TRSVEDLQWS PTENTVFASC SADASIRIWD IRAAPSKACM LTTATAHDGD VNVISWSRRE PFLLSGGDDG ALKIWDLRQF KSGSPVATFK QHVAPVTSVE WHPQDSGVFA ASGADHQITQ WDLAVERDPE AGDVEADPGL ADLPQQLLFV HQGETELKEL HWHPQCPGLL VSTALSGFTI FRTISV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards