Structure-specific endonuclease subunit SLX1 (SLX1A)

About Structure-specific endonuclease subunit SLX1

Structure-specific endonuclease subunit SLX1 (SLX1A) is a protein from Homo sapiens identified by UniProt accession Q9BQ83, 275 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Structure-specific endonuclease subunit SLX1
UniProt accession	Q9BQ83
Gene	SLX1A
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

genetic disorder · score 0.12
ulcerative colitis · score 0.07
Crohn's disease · score 0.07
psoriasis · score 0.07
ankylosing spondylitis · score 0.07
sclerosing cholangitis · score 0.07
isolated asymptomatic elevation of creatine phosphokinase · score 0.07
FRAXF syndrome · score 0.05
pentosuria · score 0.05
tonsillectomy risk measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQ83-F1	alphafold	PREDICTED	83.26	—

Amino-acid sequence (275 residues)

MGPAGVAARP GRFFGVYLLY CLNPRYRGRV YVGFTVNTAR RVQQHNGGRK KGGAWRTSGR GPWEMVLVVH GFPSSVAALR FEWAWQHPHA SRRLAHVGPR LRGETAFAFH LRVLAHMLRA PPWARLPLTL RWVRPDLRQD LCLPPPPHVP LAFGPPPPQA PAPRRRAGPF DDAEPEPDQG DPGACCSLCA QTIQDEEGPL CCPHPGCLLR AHVICLAEEF LQEEPGQLLP LEGQCPCCEK SLLWGDLIWL CQMDTEKEVE DSELEEAHWT DLLET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards