About F-box-like/WD repeat-containing protein TBL1Y
F-box-like/WD repeat-containing protein TBL1Y (TBL1Y) is a protein
from Homo sapiens identified by UniProt accession
Q9BQ87, 522 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | F-box-like/WD repeat-containing protein TBL1Y |
|---|
| UniProt accession | Q9BQ87 |
|---|
| Gene | TBL1Y |
|---|
| Organism | Homo sapiens |
|---|
| Length | 522 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (10)
Diseases linked to this target (Open Targets).
- nonsyndromic deafness · score 0.45
- neurodegenerative disease · score 0.16
- Ataxia-telangiectasia · score 0.03
- hepatocellular carcinoma · score 0.00
- nonpapillary renal cell carcinoma · score 0.00
- cancer · score 0.00
- male infertility · score 0.00
- central congenital hypothyroidism · score 0.00
- amelogenesis imperfecta · score 0.00
- Onset · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQ87-F1 | alphafold | PREDICTED | 86.83 | — |
Amino-acid sequence (522 residues)
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI SILQKGLQYV EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG EKLTQQQASA AATEASAMAK AATMTPAAIS QQNPPKNREA TVNGEENGAH EINNHSKPME IDGDVEIPPN KATVLRGHES EVFICAWNPV SDLLASGSGD STARIWNLNE NSNGGSTQLV LRHCIREGGH DVPSNKDVTS LDWNSDGTLL AMGSYDGFAR IWTENGNLAS TLGQHKGPIF ALKWNKKGNY VLSAGVDKTT IIWDAHTGEA KQQFPFHSAP ALDVDWQNNM TFASCSTDMC IHVCRLGCDH PVKTFQGHTN EVNAIKWDPS GMLLASCSDD MTLKIWSMKQ DACVHDLQAH SKEIYTIKWS PTGPATSNPN SSIMLASASF DSTVRLWDVE QGVCTHTLMK HQEPVYSVAF SPDGKYLASG SFDKYVHIWN TQSGSLVHSY QGTGGIFEVC WNARGDKVGA SASDGSVCVL DL
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