Kelch domain-containing protein 3 (KLHDC3)

About Kelch domain-containing protein 3

Kelch domain-containing protein 3 (KLHDC3) is a protein from Homo sapiens identified by UniProt accession Q9BQ90, 382 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Kelch domain-containing protein 3
UniProt accession	Q9BQ90
Gene	KLHDC3
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

body height · score 0.06
non-small cell lung carcinoma · score 0.01
acute quadriplegic myopathy · score 0.01
chronic kidney disease · score 0.00
gestational diabetes · score 0.00
cancer · score 0.00
neoplasm · score 0.00
Azoospermia · score 0.00
dermatomyositis · score 0.00
hepatocellular carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQ90-F1	alphafold	PREDICTED	94.06	—

Amino-acid sequence (382 residues)

MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN AVSLRWTKLP PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG ACNVLYAFDV NTHKWFTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQQA DCFSNDIHKL DTSTMTWTLI CTKGSPARWR DFHSATMLGS HMYVFGGRAD RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR SHSAFGYNGE LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards