About Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) is a protein
from Homo sapiens identified by UniProt accession
Q9BQ95, 431 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial |
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| UniProt accession | Q9BQ95 |
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| Gene | ECSIT |
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| Organism | Homo sapiens |
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| Length | 431 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (93)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- antiphospholipid antibody measurement · score 0.13
- left ventricular noncompaction · score 0.10
- hypertrophic cardiomyopathy · score 0.09
- hypertrophic cardiomyopathy 9 · score 0.07
- dilated cardiomyopathy 1JJ · score 0.07
- dilated cardiomyopathy · score 0.07
- dilated cardiomyopathy 1CC · score 0.06
- dilated cardiomyopathy 1W · score 0.06
- dilated cardiomyopathy 2A · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQ95-F1 | alphafold | PREDICTED | 71.57 | — |
Amino-acid sequence (431 residues)
MSWVQATLLA RGLCRAWGGT CGAALTGTSI SQVPRRLPRG LHCSAAAHSS EQSLVPSPPE PRQRPTKALV PFEDLFGQAP GGERDKASFL QTVQKFAEHS VRKRGHIDFI YLALRKMREY GVERDLAVYN QLLNIFPKEV FRPRNIIQRI FVHYPRQQEC GIAVLEQMEN HGVMPNKETE FLLIQIFGRK SYPMLKLVRL KLWFPRFMNV NPFPVPRDLP QDPVELAMFG LRHMEPDLSA RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPVFVEGP FSLWLRNKCV YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYVRSG WDNYEFDINE VEEGPVFAMC MAGAHDQATM AKWIQGLQET NPTLAQIPVV FRLAGSTREL QTSSAGLEEP PLPEDHQEED DNLQRQQQGQ S
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