About 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2) is a protein
from Homo sapiens identified by UniProt accession
Q9BQC3, 489 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 |
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| UniProt accession | Q9BQC3 |
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| Gene | DPH2 |
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| Organism | Homo sapiens |
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| Length | 489 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- developmental delay with short stature, dysmorphic facial features, and sparse hair 1 · score 0.37
- Global developmental delay · score 0.16
- ventricular septal defect · score 0.14
- Short stature · score 0.14
- Intellectual disability · score 0.12
- Macrocephaly · score 0.12
- age at first birth measurement · score 0.05
- blood protein measurement · score 0.03
- schizophrenia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQC3-F1 | alphafold | PREDICTED | 83.25 | — |
Amino-acid sequence (489 residues)
MESMFSSPAE AALQRETGVP GLLTPLPDLD GVYELERVAG FVRDLGCERV ALQFPDQLLG DAVAVAARLE ETTGSKMFIL GDTAYGSCCV DVLGAEQAGA QALIHFGPAC LSPPARPLPV AFVLRQRSVA LELCVKAFEA QNPDPKAPVV LLSEPACAHA LEALATLLRP RYLDLLVSSP AFPQPVGSLS PEPMPLERFG RRFPLAPGRR LEEYGAFYVG GSKASPDPDL DPDLSRLLLG WAPGQPFSSC CPDTGKTQDE GARAGRLRAR RRYLVERARD ARVVGLLAGT LGVAQHREAL AHLRNLTQAA GKRSYVLALG RPTPAKLANF PEVDVFVLLA CPLGALAPQL SGSFFQPILA PCELEAACNP AWPPPGLAPH LTHYADLLPG SPFHVALPPP ESELWETPDV SLITGDLRPP PAWKSSNDHG SLALTPRPQL ELAESSPAAS FLSSRSWQGL EPRLGQTPVT EAVSGRRGIA IAYEDEGSG
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