NAD-capped RNA hydrolase NUDT12 (NUDT12)

About NAD-capped RNA hydrolase NUDT12

NAD-capped RNA hydrolase NUDT12 (NUDT12) is a protein from Homo sapiens identified by UniProt accession Q9BQG2, 462 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	NAD-capped RNA hydrolase NUDT12
UniProt accession	Q9BQG2
Gene	NUDT12
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.27
brain measurement · score 0.27
risk-taking behaviour · score 0.23
sporadic amyotrophic lateral sclerosis · score 0.20
self reported educational attainment · score 0.16
PHF-tau measurement · score 0.15
BMI-adjusted waist circumference · score 0.13
rheumatoid arthritis · score 0.07
type 2 diabetes mellitus · score 0.03
intelligence · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQG2-F1	alphafold	PREDICTED	87.42	—

Amino-acid sequence (462 residues)

MSSVKRSLKQ EIVTQFHCSA AEGDIAKLTG ILSHSPSLLN ETSENGWTAL MYAARNGHPE IVQFLLEKGC DRSIVNKSRQ TALDIAVFWG YKHIANLLAT AKGGKKPWFL TNEVEECENY FSKTLLDRKS EKRNNSDWLL AKESHPATVF ILFSDLNPLV TLGGNKESFQ QPEVRLCQLN YTDIKDYLAQ PEKITLIFLG VELEIKDKLL NYAGEVPREE EDGLVAWFAL GIDPIAAEEF KQRHENCYFL HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPTCGNA TKIEEGGYKR LCLKEDCPSL NGVHNTSYPR VDPVVIMQVI HPDGTKCLLG RQKRFPPGMF TCLAGFIEPG ETIEDAVRRE VEEESGVKVG HVQYVACQPW PMPSSLMIGC LALAVSTEIK VDKNEIEDAR WFTREQVLDV LTKGKQQAFF VPPSRAIAHQ LIKHWIRINP NL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards