About Transmembrane protein 47
Transmembrane protein 47 (TMEM47) is a protein
from Homo sapiens identified by UniProt accession
Q9BQJ4, 181 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Transmembrane protein 47 |
|---|
| UniProt accession | Q9BQJ4 |
|---|
| Gene | TMEM47 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 181 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- Hypotonia · score 0.26
- Hypoplasia of the corpus callosum · score 0.26
- Global developmental delay · score 0.26
- Dandy-Walker syndrome · score 0.26
- attention deficit hyperactivity disorder · score 0.26
- Cerebellar atrophy · score 0.26
- hepatocellular carcinoma · score 0.08
- pancreatic adenocarcinoma · score 0.04
- self reported educational attainment · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQJ4-F1 | alphafold | PREDICTED | 86.53 | — |
Amino-acid sequence (181 residues)
MASAGSGMEE VRVSVLTPLK LVGLVCIFLA LCLDLGAVLS PAWVTADHQY YLSLWESCRK PASLDIWHCE STLSSDWQIA TLALLLGGAA IILIAFLVGL ISICVGSRRR FYRPVAVMLF AAVVLQVCSL VLYPIKFIET VSLKIYHEFN WGYGLAWGAT IFSFGGAILY CLNPKNYEDY Y
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