About Fermitin family homolog 1
Fermitin family homolog 1 (FERMT1) is a protein
from Homo sapiens identified by UniProt accession
Q9BQL6, 677 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Fermitin family homolog 1 |
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| UniProt accession | Q9BQL6 |
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| Gene | FERMT1 |
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| Organism | Homo sapiens |
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| Length | 677 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (166)
Diseases linked to this target (Open Targets).
- Kindler syndrome · score 0.80
- protein measurement · score 0.43
- inflammatory bowel disease · score 0.32
- eosinophil count · score 0.30
- body height · score 0.28
- Abnormality of the skin · score 0.27
- neurodegenerative disease · score 0.23
- heel bone mineral density · score 0.21
- Agents acting on the renin-angiotensin system use measurement · score 0.21
- colorectal cancer · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQL6-F1 | alphafold | PREDICTED | 80.43 | — |
Amino-acid sequence (677 residues)
MLSSTDFTFA SWELVVRVDH PNEEQQKDVT LRVSGDLHVG GVMLKLVEQI NISQDWSDFA LWWEQKHCWL LKTHWTLDKY GVQADAKLLF TPQHKMLRLR LPNLKMVRLR VSFSAVVFKA VSDICKILNI RRSEELSLLK PSGDYFKKKK KKDKNNKEPI IEDILNLESS PTASGSSVSP GLYSKTMTPI YDPINGTPAS STMTWFSDSP LTEQNCSILA FSQPPQSPEA LADMYQPRSL VDKAKLNAGW LDSSRSLMEQ GIQEDEQLLL RFKYYSFFDL NPKYDAVRIN QLYEQARWAI LLEEIDCTEE EMLIFAALQY HISKLSLSAE TQDFAGESEV DEIEAALSNL EVTLEGGKAD SLLEDITDIP KLADNLKLFR PKKLLPKAFK QYWFIFKDTS IAYFKNKELE QGEPLEKLNL RGCEVVPDVN VAGRKFGIKL LIPVADGMNE MYLRCDHENQ YAQWMAACML ASKGKTMADS SYQPEVLNIL SFLRMKNRNS ASQVASSLEN MDMNPECFVS PRCAKRHKSK QLAARILEAH QNVAQMPLVE AKLRFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVSYNRL IKIDAATGIP VTTWRFTNIK QWNVNWETRQ VVIEFDQNVF TAFTCLSADC KIVHEYIGGY IFLSTRSKDQ NETLDEDLFH KLTGGQD
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