Mitochondrial genome maintenance exonuclease 1 (MGME1)

About Mitochondrial genome maintenance exonuclease 1

Mitochondrial genome maintenance exonuclease 1 (MGME1) is a protein from Homo sapiens identified by UniProt accession Q9BQP7, 344 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Mitochondrial genome maintenance exonuclease 1
UniProt accession	Q9BQP7
Gene	MGME1
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

mitochondrial DNA depletion syndrome 11 · score 0.71
Progressive external ophthalmoplegia - myopathy - emaciation · score 0.46
mitochondrial disease · score 0.37
mean corpuscular hemoglobin · score 0.37
erythrocyte count · score 0.31
low density lipoprotein cholesterol measurement · score 0.29
mitochondrial DNA measurement · score 0.27
total cholesterol measurement · score 0.27
sex hormone-binding globulin measurement · score 0.26
bilirubin measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQP7-F1	alphafold	PREDICTED	75.55	—

Amino-acid sequence (344 residues)

MKMKLFQTIC RQLRSSKFSV ESAALVAFST SSYSCGRKKK VNPYEEVDQE KYSNLVQSVL SSRGVAQTPG SVEEDALLCG PVSKHKLPNQ GEDRRVPQNW FPIFNPERSD KPNASDPSVP LKIPLQRNVI PSVTRVLQQT MTKQQVFLLE RWKQRMILEL GEDGFKEYTS NVFLQGKRFH EALESILSPQ ETLKERDENL LKSGYIESVQ HILKDVSGVR ALESAVQHET LNYIGLLDCV AEYQGKLCVI DWKTSEKPKP FIQSTFDNPL QVVAYMGAMN HDTNYSFQVQ CGLIVVAYKD GSPAHPHFMD AELCSQYWTK WLLRLEEYTE KKKNQNIQKP EYSE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards