Serine protease 27 (PRSS27)

About Serine protease 27

Serine protease 27 (PRSS27) is a protein from Homo sapiens identified by UniProt accession Q9BQR3, 290 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Serine protease 27
UniProt accession	Q9BQR3
Gene	PRSS27
Organism	Homo sapiens
Length	290 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.09
X-linked severe congenital neutropenia · score 0.06
esophageal squamous cell carcinoma · score 0.05
neutropenia, severe congenital, 2, autosomal dominant · score 0.05
psoriasis · score 0.04
neutropenia-monocytopenia-deafness syndrome · score 0.04
esophageal adenocarcinoma · score 0.04
body fat percentage · score 0.04
neutropenia, severe congenital, 1, autosomal dominant · score 0.04
Barrett's esophagus · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQR3-F1	alphafold	PREDICTED	88.49	—

Amino-acid sequence (290 residues)

MRRPAAVPLL LLLCFGSQRA KAATACGRPR MLNRMVGGQD TQEGEWPWQV SIQRNGSHFC GGSLIAEQWV LTAAHCFRNT SETSLYQVLL GARQLVQPGP HAMYARVRQV ESNPLYQGTA SSADVALVEL EAPVPFTNYI LPVCLPDPSV IFETGMNCWV TGWGSPSEED LLPEPRILQK LAVPIIDTPK CNLLYSKDTE FGYQPKTIKN DMLCAGFEEG KKDACKGDSG GPLVCLVGQS WLQAGVISWG EGCARQNRPG VYIRVTAHHN WIHRIIPKLQ FQPARLGGQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards