Mitochondrial 2-oxodicarboxylate carrier (SLC25A21)

About Mitochondrial 2-oxodicarboxylate carrier

Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) is a protein from Homo sapiens identified by UniProt accession Q9BQT8, 299 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Mitochondrial 2-oxodicarboxylate carrier
UniProt accession	Q9BQT8
Gene	SLC25A21
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

mitochondrial DNA depletion syndrome 18 · score 0.52
vital capacity · score 0.47
mean corpuscular volume · score 0.45
reticulocyte count · score 0.38
protein measurement · score 0.36
forced expiratory volume · score 0.35
vertebral disorder · score 0.35
type 1 diabetes mellitus · score 0.32
PHF-tau measurement · score 0.31
vertebral column disorder · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQT8-F1	alphafold	PREDICTED	88.83	—

Amino-acid sequence (299 residues)

MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP NSYKSLVDSF RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL LGYVSLSPAL TFAIAGLGSG LTEAIVVNPF EVVKVGLQAN RNTFAEQPST VGYARQIIKK EGWGLQGLNK GLTATLGRHG VFNMVYFGFY YNVKNMIPVN KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYRTC FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards