About Coronin-1B
Coronin-1B (CORO1B) is a protein
from Homo sapiens identified by UniProt accession
Q9BR76, 489 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Coronin-1B |
|---|
| UniProt accession | Q9BR76 |
|---|
| Gene | CORO1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 489 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.21
- mean corpuscular hemoglobin · score 0.20
- mean corpuscular hemoglobin concentration · score 0.16
- genetic disorder · score 0.12
- mean reticulocyte volume · score 0.11
- hemoglobin measurement · score 0.08
- Abnormality of refraction · score 0.06
- apolipoprotein A 1 measurement · score 0.06
- sunburn · score 0.05
- erythrocyte count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BR76-F1 | alphafold | PREDICTED | 89.43 | — |
Amino-acid sequence (489 residues)
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV IVEASGGGAF LVLPLSKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS GSEDCTVMVW QIPENGLTSP LTEPVVVLEG HTKRVGIIAW HPTARNVLLS AGCDNVVLIW NVGTAEELYR LDSLHPDLIY NVSWNHNGSL FCSACKDKSV RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTTGFS RMSERQLALW DPENLEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITEE PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM TVPRKSDLFQ DDLYPDTAGP EAALEAEEWV SGRDADPILI SLREAYVPSK QRDLKISRRN VLSDSRPAMA PGSSHLGAPA STTTAADATP SGSLARAGEA GKLEEVMQEL RALRALVKEQ GDRICRLEEQ LGRMENGDA
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