About 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (PLCD4) is a protein
from Homo sapiens identified by UniProt accession
Q9BRC7, 762 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
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| UniProt accession | Q9BRC7 |
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| Gene | PLCD4 |
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| Organism | Homo sapiens |
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| Length | 762 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (126)
Diseases linked to this target (Open Targets).
- endometrial cancer · score 0.23
- cutaneous melanoma · score 0.18
- body height · score 0.14
- breast adenocarcinoma · score 0.13
- bilirubin measurement · score 0.12
- reticulocyte count · score 0.11
- azoospermia · score 0.08
- white matter microstructure measurement · score 0.08
- IGF-1 measurement · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BRC7-F1 | alphafold | PREDICTED | 88.88 | — |
Amino-acid sequence (762 residues)
MASLLQDQLT TDQDLLLMQE GMPMRKVRSK SWKKLRYFRL QNDGMTVWHA RQARGSAKPS FSISDVETIR NGHDSELLRS LAEELPLEQG FTIVFHGRRS NLDLMANSVE EAQIWMRGLQ LLVDLVTSMD HQERLDQWLS DWFQRGDKNQ DGKMSFQEVQ RLLHLMNVEM DQEYAFSLFQ AADTSQSGTL EGEEFVQFYK ALTKRAEVQE LFESFSADGQ KLTLLEFLDF LQEEQKERDC TSELALELID RYEPSDSGKL RHVLSMDGFL SYLCSKDGDI FNPACLPIYQ DMTQPLNHYF ICSSHNTYLV GDQLCGQSSV EGYIRALKRG CRCVEVDVWD GPSGEPVVYH GHTLTSRILF KDVVATVAQY AFQTSDYPVI LSLETHCSWE QQQTMARHLT EILGEQLLST TLDGVLPTQL PSPEELRRKI LVKGKKLTLE EDLEYEEEEA EPELEESELA LESQFETEPE PQEQNLQNKD KKKKSKPILC PALSSLVIYL KSVSFRSFTH SKEHYHFYEI SSFSETKAKR LIKEAGNEFV QHNTWQLSRV YPSGLRTDSS NYNPQELWNA GCQMVAMNMQ TAGLEMDICD GHFRQNGGCG YVLKPDFLRD IQSSFHPEKP ISPFKAQTLL IQVISGQQLP KVDKTKEGSI VDPLVKVQIF GVRLDTARQE TNYVENNGFN PYWGQTLCFR VLVPELAMLR FVVMDYDWKS RNDFIGQYTL PWTCMQQGYR HIHLLSKDGI SLRPASIFVY ICIQEGLEGD ES
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