Proton-coupled zinc antiporter SLC30A2 (SLC30A2)

About Proton-coupled zinc antiporter SLC30A2

Proton-coupled zinc antiporter SLC30A2 (SLC30A2) is a protein from Homo sapiens identified by UniProt accession Q9BRI3, 372 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Proton-coupled zinc antiporter SLC30A2
UniProt accession	Q9BRI3
Gene	SLC30A2
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

zinc deficiency, transient neonatal · score 0.62
genetic disorder · score 0.19
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
forced expiratory volume · score 0.06
Zinc deficiency · score 0.06
peak expiratory flow · score 0.04
QRS complex · score 0.04
QRS amplitude · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BRI3-F1	alphafold	PREDICTED	77.89	—

Amino-acid sequence (372 residues)

MEAKEKQHLL DARPAIRSYT GSLWQEGAGW IPLPRPGLDL QAIELAAQSN HHCHAQKGPD SHCDPKKGKA QRQLYVASAI CLLFMIGEVV GGYLAHSLAV MTDAAHLLTD FASMLISLFS LWMSSRPATK TMNFGWQRAE ILGALVSVLS IWVVTGVLVY LAVERLISGD YEIDGGTMLI TSGCAVAVNI IMGLTLHQSG HGHSHGTTNQ QEENPSVRAA FIHVIGDFMQ SMGVLVAAYI LYFKPEYKYV DPICTFVFSI LVLGTTLTIL RDVILVLMEG TPKGVDFTAV RDLLLSVEGV EALHSLHIWA LTVAQPVLSV HIAIAQNTDA QAVLKTASSR LQGKFHFHTV TIQIEDYSED MKDCQACQGP SD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards