Serine/arginine-rich splicing factor 8 (SRSF8)

About Serine/arginine-rich splicing factor 8

Serine/arginine-rich splicing factor 8 (SRSF8) is a protein from Homo sapiens identified by UniProt accession Q9BRL6, 282 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Serine/arginine-rich splicing factor 8
UniProt accession	Q9BRL6
Gene	SRSF8
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

erythrocyte count · score 0.10
mean corpuscular volume · score 0.10
mean corpuscular hemoglobin · score 0.09
Red cell distribution width · score 0.09
mean corpuscular hemoglobin concentration · score 0.08
mean reticulocyte volume · score 0.07
red blood cell density measurement · score 0.05
PHF-tau measurement · score 0.04
aspartate aminotransferase measurement · score 0.04
electrocardiography · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BRL6-F1	alphafold	PREDICTED	58.03	—

Amino-acid sequence (282 residues)

MSCGRPPPDV DGMITLKVDN LTYRTSPDSL RRVFEKYGRV GDVYIPREPH TKAPRGFAFV RFHDRRDAQD AEAAMDGAEL DGRELRVQVA RYGRRDLPRS RQGEPRGRSR GGGYGRRSRS YGRRSRSPRR RHRSRSRGPS CSRSRSRSRY RGSRYSRSPY SRSPYSRSRY SRSPYSRSRY RESRYGGSHY SSSGYSNSRY SRYHSSRSHS KSGSSTSSRS ASTSKSSSAR RSKSSSVSRS RSRSRSSSMT RSPPRVSKRK SKSRSRSKRP PKSPEEEGQM SS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards