About La-related protein 6
La-related protein 6 (LARP6) is a protein
from Homo sapiens identified by UniProt accession
Q9BRS8, 491 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | La-related protein 6 |
|---|
| UniProt accession | Q9BRS8 |
|---|
| Gene | LARP6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 491 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- metabolite measurement · score 0.25
- brain volume measurement · score 0.13
- neurodegenerative disease · score 0.11
- glucuronate measurement · score 0.10
- cortical thickness · score 0.10
- appendicular lean mass · score 0.09
- eosinophil count · score 0.08
- FEV/FVC ratio · score 0.06
- eosinophil percentage of leukocytes · score 0.05
- cortical surface area measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BRS8-F1 | alphafold | PREDICTED | 60.20 | — |
Amino-acid sequence (491 residues)
MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V
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