About E3 ubiquitin-protein ligase TRIM56
E3 ubiquitin-protein ligase TRIM56 (TRIM56) is a protein
from Homo sapiens identified by UniProt accession
Q9BRZ2, 755 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM56 |
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| UniProt accession | Q9BRZ2 |
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| Gene | TRIM56 |
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| Organism | Homo sapiens |
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| Length | 755 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- Red cell distribution width · score 0.17
- apolipoprotein A 1 measurement · score 0.10
- neoplasm · score 0.09
- glioblastoma multiforme · score 0.09
- Miyoshi myopathy · score 0.08
- lung adenocarcinoma · score 0.07
- non-alcoholic fatty liver disease · score 0.07
- nail-patella syndrome · score 0.07
- Zika virus infectious disease · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BRZ2-F1 | alphafold | PREDICTED | 76.22 | — |
Amino-acid sequence (755 residues)
MVSHGSSPSL LEALSSDFLA CKICLEQLRA PKTLPCLHTY CQDCLAQLAD GGRVRCPECR ETVPVPPEGV ASFKTNFFVN GLLDLVKARA CGDLRAGKPA CALCPLVGGT STGGPATARC LDCADDLCQA CADGHRCTRQ THTHRVVDLV GYRAGWYDEE ARERQAAQCP QHPGEALRFL CQPCSQLLCR ECRLDPHLDH PCLPLAEAVR ARRPGLEGLL AGVDNNLVEL EAARRVEKEA LARLREQAAR VGTQVEEAAE GVLRALLAQK QEVLGQLRAH VEAAEEAARE RLAELEGREQ VARAAAAFAR RVLSLGREAE ILSLEGAIAQ RLRQLQGCPW APGPAPCLLP QLELHPGLLD KNCHLLRLSF EEQQPQKDGG KDGAGTQGGE ESQSRREDEP KTERQGGVQP QAGDGAQTPK EEKAQTTREE GAQTLEEDRA QTPHEDGGPQ PHRGGRPNKK KKFKGRLKSI SREPSPALGP NLDGSGLLPR PIFYCSFPTR MPGDKRSPRI TGLCPFGPRE ILVADEQNRA LKRFSLNGDY KGTVPVPEGC SPCSVAALQS AVAFSASARL YLINPNGEVQ WRRALSLSQA SHAVAALPSG DRVAVSVAGH VEVYNMEGSL ATRFIPGGKA SRGLRALVFL TTSPQGHFVG SDWQQNSVVI CDGLGQVVGE YKGPGLHGCQ PGSVSVDKKG YIFLTLREVN KVVILDPKGS LLGDFLTAYH GLEKPRVTTM VDGRYLVVSL SNGTIHIFRV RSPDS
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