About Centromere protein K
Centromere protein K (CENPK) is a protein
from Homo sapiens identified by UniProt accession
Q9BS16, 269 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Centromere protein K |
|---|
| UniProt accession | Q9BS16 |
|---|
| Gene | CENPK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 269 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- reticulocyte count · score 0.32
- brain volume measurement · score 0.27
- neuroimaging measurement · score 0.24
- brain measurement · score 0.21
- feeling tense measurement · score 0.19
- refractive error measurement · score 0.19
- DNA methylation · score 0.17
- reticulocyte measurement · score 0.17
- thalamus volume · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BS16-F1 | alphafold | PREDICTED | 80.98 | — |
Amino-acid sequence (269 residues)
MNQEDLDPDS TTDVGDVTNT EEELIRECEE MWKDMEECQN KLSLIGTETL TDSNAQLSLL IMQVKCLTAE LSQWQKKTPE TIPLTEDVLI TLGKEEFQKL RQDLEMVLST KESKNEKLKE DLEREQRWLD EQQQIMESLN VLHSELKNKV ETFSESRIFN ELKTKMLNIK EYKEKLLSTL GEFLEDHFPL PDRSVKKKKK NIQESSVNLI TLHEMLEILI NRLFDVPHDP YVKISDSFWP PYVELLLRNG IALRHPEDPT RIRLEAFHQ
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