Zona pellucida-binding protein 1 (ZPBP)

About Zona pellucida-binding protein 1

Zona pellucida-binding protein 1 (ZPBP) is a protein from Homo sapiens identified by UniProt accession Q9BS86, 351 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Zona pellucida-binding protein 1
UniProt accession	Q9BS86
Gene	ZPBP
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

spermatogenic failure 66 · score 0.60
monocyte percentage of leukocytes · score 0.44
neurodegenerative disease · score 0.42
male infertility due to globozoospermia · score 0.39
neutrophil percentage of granulocytes · score 0.27
self reported educational attainment · score 0.27
eosinophil count · score 0.25
depressive symptom measurement · score 0.22
neuroticism measurement · score 0.22
monocyte count · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BS86-F1	alphafold	PREDICTED	82.03	—

Amino-acid sequence (351 residues)

MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP RAFRLTKDSV KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF QWYGPKGKVV SVENRTAQIT STGSLVFQNF EESMSGIYTC FLEYKPTVEE IVKRLQLKYA IYAYREPHYY YQFTARYHAA PCNSIYNISF EKKLLQILSK LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD TEKGPKRCTD HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards