About Endosomal/lysosomal proton channel TMEM175
Endosomal/lysosomal proton channel TMEM175 (TMEM175) is a protein
from Homo sapiens identified by UniProt accession
Q9BSA9, 504 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Endosomal/lysosomal proton channel TMEM175 |
|---|
| UniProt accession | Q9BSA9 |
|---|
| Gene | TMEM175 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 504 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.45
- triglyceride measurement · score 0.43
- BMI-adjusted waist-hip ratio · score 0.40
- BMI-adjusted waist circumference · score 0.38
- alcohol drinking · score 0.37
- late-onset Parkinson disease · score 0.37
- high density lipoprotein cholesterol measurement · score 0.35
- alcohol consumption measurement · score 0.34
- smoking status measurement · score 0.34
- age at onset · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSA9-F1 | alphafold | PREDICTED | 81.73 | — |
Amino-acid sequence (504 residues)
MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV MILPVTHTEI SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ VVGKTDDTLA LLNLACMMTI TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI GVVQALIVGY AFHFPHLLSP QIQRSAHRAL YRRHVLGIVL QGPALCFAAA IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP SAHPVEVFSF DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA FVGGLPLAYQ QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH QAETLQPSVW FGGREHVLMF AKLALYPCAS LLAFASTCLL SRFSVGIFHL MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA RPEHPPPAPT GQDDPQSQLL PAPC
Explore Endosomal/lysosomal proton channel TMEM175 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets