About Translational activator of cytochrome c oxidase 1
Translational activator of cytochrome c oxidase 1 (TACO1) is a protein
from Homo sapiens identified by UniProt accession
Q9BSH4, 297 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Translational activator of cytochrome c oxidase 1 |
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| UniProt accession | Q9BSH4 |
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| Gene | TACO1 |
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| Organism | Homo sapiens |
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| Length | 297 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.61
- mitochondrial complex 4 deficiency, nuclear type 8 · score 0.60
- cytochrome-c oxidase deficiency disease · score 0.50
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.46
- breast adenocarcinoma · score 0.23
- Leigh syndrome · score 0.19
- genetic disorder · score 0.19
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.18
- body mass index · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSH4-F1 | alphafold | PREDICTED | 84.39 | — |
Amino-acid sequence (297 residues)
MSAWAAASLS RAAARCLLAR GPGVRAAPPR DPRPSHPEPR GCGAAPGRTL HFTAAVPAGH NKWSKVRHIK GPKDVERSRI FSKLCLNIRL AVKEGGPNPE HNSNLANILE VCRSKHMPKS TIETALKMEK SKDTYLLYEG RGPGGSSLLI EALSNSSHKC QADIRHILNK NGGVMAVGAR HSFDKKGVIV VEVEDREKKA VNLERALEMA IEAGAEDVKE TEDEEERNVF KFICDASSLH QVRKKLDSLG LCSVSCALEF IPNSKVQLAE PDLEQAAHLI QALSNHEDVI HVYDNIE
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